


Great thanks to the speakers.
You made it possible to have this symposium with your exciting talks
on precision cancer medicine in Helsinki - MISSION POSSIBLE
For more information, please contact ican-fci@helsinki.fi
VENUE: Hilton Helsinki Kalastajatorppa, Conference and Events Center, Kalastajatorpantie 1, Helsinki, tel: +358-945811
Thursday, September 22, 2022 - Siirtomaasali 1
8:00 – Breakfast & Registration
9:00 Opening words. Satu Mustjoki, iCAN Scientific Director, University of Helsinki & HUS Helsinki University Hospital
9:05 Awarding of the Eero Saksela prize by Vesa Kataja, Chair of the Scientific Advisory Board of the Finnish Cancer Institute
9:15 Special lecture: Kari Alitalo, University of Helsinki: A proxy of stemness and progression in intestinal cancer
10:00 Keynote: Peter Kraft, Harvard University: Polygenic risk scores and tailored cancer screening
10:45 Coffee, posters, and exhibition
SESSION 1. Chairs: Johanna Arola & Martti Färkkilä
11:15 Christian Meisel, Hedera Dx: Actionable ctDNA based insights for precision cancer medicine
11:45 Jesús Bañales, Biodonostia: Genetic background of primary sclerosing cholangitis associated cholangiocarcinoma (PSC-CCA)
12:15 Cyriel Ponsioen, Amsterdam AMC: Primary sclerosing cholangitis (PSC) dysplasia surveillance
12:45 Short presentation selected from abstracts: Nelli Sjöblom, HUS Helsinki University Hospital: Next generation sequencing of brush samples may improve detection of biliary neoplasia in PSC patients
13:00 – 14:00 Lunch, posters, and exhibition
SESSION 2. Chairs: Caroline Heckman & Markus Vähä-Koskela
14:00 Daniel Peeper, Netherlands Cancer Institute: Rational concepts for tumor & immune cell therapy combinations
14:30 Karin de Visser, Netherlands Cancer Institute: Innate-adaptive immune cell crosstalk dictates response to immune checkpoint blockade in breast cancer
15:00 René Medema, Netherlands Cancer Institute: Chromatin-dependent control of the DNA damage response
15:30 Eero Saksela prize winner presentation Anniina Färkkilä, University of Helsinki and Helsinki University Hospital: Immunogenomic profiling for precision oncology in ovarian cancer
15:45 Group Photo, coffee
SESSION 3. Chairs: Tomi Mäkelä & Johanna Ivaska
16:15 Johanna Ivaska, University of Turku: Targeting KRAS-mutant cancers by disrupting KRAS-SHANK3 interaction
16:45 Francesca M. Buffa, University of Oxford: Machine Learning and Systems Biology approaches in Precision Oncology
17:15 Pekka Katajisto, University of Helsinki: Stem cells and tumorigenesis – a fight between self-renewing cells
17:45 Eero Saksela prize winner presentation Toni Seppälä, University of Tampere and Tampere University Hospital: Hereditary cancer paving the way to personalised medicine
18:00 Adjournement
19:00- Dinner at Kalastajatorppa, Pyöreä Sali
Friday, September 23, 2022 - Siirtomaasali 1
7:45 Breakfast & Registration
SESSION 4. Chairs: Tomi Mäkelä & Minna Anttonen
8:30 Special lecture: Bettina Ryll, Melanoma Patient Network Europe: From good to great: What patients can do for your research?
9:00 Panel discussion on patient involvement.
Moderators: Sara Lassfolk and Marketta Liljeström, iCAN Patient and Citizen Advisory Board.
Panel members: Sampsa Hautaniemi, University of Helsinki, Jarmo Wahlfors, Cancer Foundations Finland, Aino Kormilainen, HUS
9:30 Coffee, posters, and exhibition
SESSION 5. Chairs: Ilkka Ilonen & Tiina Vesterinen
10:00 Keynote: Pasi Jänne, Dana-Farber Cancer Institute, Harvard Medical School: Beyond the magic bullet
10:45 Prasad Adusumilli, Memorial Sloan Kettering Cancer Center: CAR-T cell therapy for solid tumors; new opportunities and challenges
11:15 Lynette Sholl, Brigham and Women’s Hospital/Harvard Medical School: Molecular diagnostics of cancer to support individualized therapy: perspectives from a clinical lab
11:45 Åslaug Helland, Oslo University Hospital: Personalized medicine in thoracic oncology; where are we now and where we are going – where we have the most to gain?
12:15 – 13:30 Lunch, posters, and exhibition
SESSION 6. Chairs: Sirpa Leppä & Päivi Ojala
13:30 Marco Gerlinger, Barts Cancer Institute and St Bartholomew’s Hospital, London: Gastrointestinal cancer evolution: mechanisms and implications for precision therapy
14:00 Kjetil Taskén, Institute of Cancer Research, Oslo University Hospital: A national precision cancer medicine implementation initiative for Norway
14:30 Short presentation selected from abstracts, Sakari Vanharanta, University of Helsinki: Lineage factor-dependent oncogenic signaling in kidney cancer
14:45 Coffee, posters, and exhibition
SESSION 7. Chairs: Päivi Ojala & Sirpa Leppä
15:15 Keynote: Michel Sadelain, Memorial Sloan Kettering Cancer Center: CAR T cells and the Living Drug Concept
16:00 Dario Campana, NUS Yong Loo Lin School of Medicine: Disrupting the treatment of lymphoid malignancies with CAR-T cells
16:30 Maria Themeli, Amsterdam UMC: Designing optimal dual-targeting of CAR T cells: the BETTER gate
17:00 Satu Mustjoki, University of Helsinki: Mechanisms of natural killer cell immune evasion by functional immune profiling
17:30 Closing words, Johanna Arola, the Chair of the Organizing Committee
17:45 Adjournement
Organising committee:
Johanna Arola, chair
Tomi Mäkelä, vice chair
Caroline Heckman
Päivi Ojala
Sirpa Leppä
Ilkka Ilonen
Secretariat:
Tiina Vesterinen, FCI
Leena Karhinen, iCAN
Marketta Liljeström, iCAN PCAB
Satu Sankkila, iCAN
Saija Piiroinen, iCAN
Contact: ican-fci@helsinki.fi
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