Symposium – iCAN – Digital Precision Cancer Medicine

Great thanks to the speakers. 
You made it possible to have this symposium with your exciting talks
on precision cancer medicine in Helsinki - MISSION POSSIBLE

For more information, please contact ican-fci@helsinki.fi

VENUE: Hilton Helsinki Kalastajatorppa, Conference and Events Center, Kalastajatorpantie 1, Helsinki, tel: +358-945811

Thursday, September 22, 2022 - Siirtomaasali 1

8:00 – Breakfast & Registration

9:00 Opening words. Satu Mustjoki, iCAN Scientific Director, University of Helsinki & HUS Helsinki University Hospital

9:05 Awarding of the Eero Saksela prize by Vesa Kataja, Chair of the Scientific Advisory Board of the Finnish Cancer Institute

9:15 Special lecture: Kari Alitalo, University of Helsinki: A proxy of stemness and progression in intestinal cancer

10:00 Keynote: Peter Kraft, Harvard University: Polygenic risk scores and tailored cancer screening

10:45 Coffee, posters, and exhibition

SESSION 1. Chairs: Johanna Arola & Martti Färkkilä

11:15 Christian Meisel, Hedera Dx: Actionable ctDNA based insights for precision cancer medicine

11:45 Jesús Bañales, Biodonostia: Genetic background of primary sclerosing cholangitis associated cholangiocarcinoma (PSC-CCA)

12:15 Cyriel Ponsioen, Amsterdam AMC: Primary sclerosing cholangitis (PSC) dysplasia surveillance

12:45 Short presentation selected from abstracts: Nelli Sjöblom, HUS Helsinki University Hospital: Next generation sequencing of brush samples may improve detection of biliary neoplasia in PSC patients

13:00 – 14:00 Lunch, posters, and exhibition

SESSION 2. Chairs: Caroline Heckman & Markus Vähä-Koskela

14:00 Daniel Peeper, Netherlands Cancer Institute: Rational concepts for tumor & immune cell therapy combinations

14:30 Karin de Visser, Netherlands Cancer Institute: Innate-adaptive immune cell crosstalk dictates response to immune checkpoint blockade in breast cancer

15:00 René Medema, Netherlands Cancer Institute: Chromatin-dependent control of the DNA damage response

15:30 Eero Saksela prize winner presentation Anniina Färkkilä, University of Helsinki and Helsinki University Hospital: Immunogenomic profiling for precision oncology in ovarian cancer

15:45 Group Photo, coffee

SESSION 3. Chairs: Tomi Mäkelä & Johanna Ivaska

16:15 Johanna Ivaska, University of Turku: Targeting KRAS-mutant cancers by disrupting KRAS-SHANK3 interaction

16:45 Francesca M. Buffa, University of Oxford: Machine Learning and Systems Biology approaches in Precision Oncology

17:15 Pekka Katajisto, University of Helsinki: Stem cells and tumorigenesis – a fight between self-renewing cells

17:45 Eero Saksela prize winner presentation Toni Seppälä, University of Tampere and Tampere University Hospital: Hereditary cancer paving the way to personalised medicine

18:00 Adjournement

19:00- Dinner at Kalastajatorppa, Pyöreä Sali

Friday, September 23, 2022 - Siirtomaasali 1

7:45 Breakfast & Registration

SESSION 4. Chairs: Tomi Mäkelä & Minna Anttonen

8:30 Special lecture: Bettina Ryll, Melanoma Patient Network Europe: From good to great: What patients can do for your research?

9:00 Panel discussion on patient involvement.

Moderators: Sara Lassfolk and Marketta Liljeström, iCAN Patient and Citizen Advisory Board.

Panel members: Sampsa Hautaniemi, University of Helsinki, Jarmo Wahlfors, Cancer Foundations Finland, Aino Kormilainen, HUS

9:30 Coffee, posters, and exhibition

SESSION 5. Chairs: Ilkka Ilonen & Tiina Vesterinen

10:00 Keynote: Pasi Jänne, Dana-Farber Cancer Institute, Harvard Medical School: Beyond the magic bullet

10:45 Prasad Adusumilli, Memorial Sloan Kettering Cancer Center: CAR-T cell therapy for solid tumors; new opportunities and challenges

11:15 Lynette Sholl, Brigham and Women’s Hospital/Harvard Medical School: Molecular diagnostics of cancer to support individualized therapy: perspectives from a clinical lab

11:45 Åslaug Helland, Oslo University Hospital: Personalized medicine in thoracic oncology; where are we now and where we are going – where we have the most to gain?

12:15 – 13:30 Lunch, posters, and exhibition

SESSION 6. Chairs: Sirpa Leppä & Päivi Ojala

13:30 Marco Gerlinger, Barts Cancer Institute and St Bartholomew’s Hospital, London: Gastrointestinal cancer evolution: mechanisms and implications for precision therapy

14:00 Kjetil Taskén, Institute of Cancer Research, Oslo University Hospital: A national precision cancer medicine implementation initiative for Norway

14:30 Short presentation selected from abstracts, Sakari Vanharanta, University of Helsinki: Lineage factor-dependent oncogenic signaling in kidney cancer

14:45 Coffee, posters, and exhibition

SESSION 7. Chairs: Päivi Ojala & Sirpa Leppä

15:15 Keynote: Michel Sadelain, Memorial Sloan Kettering Cancer Center: CAR T cells and the Living Drug Concept

16:00 Dario Campana, NUS Yong Loo Lin School of Medicine: Disrupting the treatment of lymphoid malignancies with CAR-T cells

16:30 Maria Themeli, Amsterdam UMC: Designing optimal dual-targeting of CAR T cells: the BETTER gate

17:00 Satu Mustjoki, University of Helsinki: Mechanisms of natural killer cell immune evasion by functional immune profiling

17:30 Closing words, Johanna Arola, the Chair of the Organizing Committee

17:45 Adjournement

Organising committee:

Johanna Arola, chair

Tomi Mäkelä, vice chair

Caroline Heckman

Päivi Ojala

Sirpa Leppä

Ilkka Ilonen

Secretariat:

Tiina Vesterinen, FCI

Leena Karhinen, iCAN

Marketta Liljeström, iCAN PCAB

Satu Sankkila, iCAN

Saija Piiroinen, iCAN

Contact: ican-fci@helsinki.fi