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1.Lahde, M; Heino, S; Hogstrom, J; Kaijalainen, S; Anisimov, A; Flanagan, D; Kallio, P; Leppanen, VM; Ristimaki, A; Ritvos, O; Wu, K; Tammela, T; Hodder, M; Sansom, OJ; Alitalo, K: Expression of R-Spondin 1 in Apc(Min/+) Mice Suppresses Growth of Intestinal Adenomas by Altering Wnt and Transforming Growth Factor Beta Signaling. In: Gastroenterology, 160 (1), pp. 245–259, 2021, ISSN: 0016-5085. (Type: Journal Article | Abstract | Links | BibTeX)
2.Feurstein, S; Churpek, JE; Walsh, T; Keel, S; Hakkarainen, M; Schroeder, T; Germing, U; Geyh, S; Heuser, M; Thol, F; Pohlkamp, C; Haferlach, T; Gao, JH; Owen, C; Goehring, G; Schlegelberger, B; Verma, D; Krause, DS; Gao, GM; Cronin, T; Gulsuner, S; Lee, M; Pritchard, CC; Subramanian, HP; del Gaudio, D; Li, ZJ; Das, S; Kilpivaara, O; Wartiovaara-Kautto, U; Wang, EIS; Griffiths, EA; Dohner, K; Dohner, H; King, MC; Godley, LA: Germline variants drive myelodysplastic syndrome in young adults. In: Leukemia, 2021, ISSN: 0887-6924. (Type: Journal Article | Links | BibTeX)
3.Ianevski, A; Lahtela, J; Javarappa, KK; Sergeev, P; Ghimire, BR; Gautam, P; Vaha-Koskela, M; Turunen, L; Linnavirta, N; Kuusanmaki, H; Kontro, M; Porkka, K; Heckman, CA; Mattila, P; Wennerberg, K; Giri, AK; Aittokallio, T: Patient-tailored design for selective co-inhibition of leukemic cell subpopulations. In: Science Advances, 7 (8), 2021, ISSN: 2375-2548. (Type: Journal Article | Links | BibTeX)
4.Dustin J. Flanagan, Nalle Pentinmikko, Kalle Luopajärvi, Nicky J. Willis, Kathryn Gilroy, Alexander P. Raven, Lynn Mcgarry, Johanna I. Englund, Anna T. Webb, Sandra Scharaw, Nadia Nasreddin, Michael C. Hodder, Rachel A. Ridgway, Emma Minnee, Nathalie Sphyris, Ella Gilchrist, Arafath K. Najumudeen, Beatrice Romagnolo, Christine Perret, Ann C. Williams, Hans Clevers, Pirjo Nummela, Marianne Lähde, Kari Alitalo, Ville Hietakangas, Ann Hedley, William Clark, Colin Nixon, Kristina Kirschner, E. Yvonne Jones, Ari Ristimäki, Simon J. Leedham, Paul V. Fish, Jean-Paul Vincent, Pekka Katajisto & Owen J. : NOTUM from Apc-mutant cells biases clonal competition to initiate cancer. In: Nature, 594 (7863), pp. 430–+, 2021, ISSN: 0028-0836. (Type: Journal Article | Links | BibTeX)
5.Autio, M; Leivonen, SK; Bruck, O; Mustjoki, S; Jorgensen, JM; Karjalainen-Lindsberg, ML; Beiske, K; Holte, H; Pellinen, T; Leppa, S: Immune cell constitution in the tumor microenvironment predicts the outcome in diffuse large B-cell lymphoma. In: Haematologica, 106 (3), pp. 718–729, 2021, ISSN: 0390-6078. (Type: Journal Article | Links | BibTeX)
6.Stenman, S; Bychkov, D; Kucukel, H; Linder, N; Haglund, C; Arola, J; Lundin, J: Antibody Supervised Training of a Deep Learning Based Algorithm for Leukocyte Segmentation in Papillary Thyroid Carcinoma. In: IEEE Journal of Biomedical and Health Informatics, 25 (2), pp. 422 – 428, 2021, ISSN: 2168-2194. (Type: Journal Article | Links | BibTeX)
7.Satu Mustjoki, M.D., and Neal S. Young, M.D. : Somatic Mutations in “Benign” Disease. In: NEJM, in press , 2021. (Type: Journal Article | Links | BibTeX)
8.Mikaela Grönholm, Michaela Feodoroff, Gabriella Antignani, Beatriz Martins, Firas Hamdan, Vincenzo Cerullo: Patient-Derived Organoids for Precision Cancer Immunotherapy. In: Cancer Research, 81 (12), pp. 3149–3155, 2021, ISSN: 0008-5472. (Type: Journal Article | Links | BibTeX)
9.Zhou J, Gelot C, Pantelidou C, Li A, Yücel A, E. Davis RE, Färkkilä A, Kochupurakkal B, Aleem Syed, Shapiro GI, Tainer JA, Blagg BSJ, Ceccaldi R, and D’Andrea AD: A first-in-class polymerase theta inhibitor selectively targets homologous-recombination-deficient tumors. In: Nature Cancer, 2 (6), pp. 598–610, 2021. (Type: Journal Article | Links | BibTeX)
10.Oikkonen, J; Zhang, KY; Salminen, L; Schulman, I; Lavikka, K; Andersson, N; Ojanpera, E; Hietanen, S; Grenman, S; Lehtonen, R; Huhtinen, K; Carpen, O; Hynninen, J; Farkkila, A; Hautaniemi, S: Prospective Longitudinal ctDNA Workflow Reveals Clinically Actionable Alterations in Ovarian Cancer. In: JCO Precision Oncology, 3 (3), pp. 1–12, 2019, ISSN: 2473-4284. (Type: Journal Article | Links | BibTeX)
11.Haikala, HM; Anttila, JM; Marques, E; Raatikainen, T; Ilander, M; Hakanen, H; Ala-Hongisto, H; Savelius, M; Balboa, D; Von Eyss, B; Eskelinen, V; Munne, P; Nieminen, AI; Otonkoski, T; Schuler, J; Laajala, TD; Aittokallio, T; Sihto, H; Mattson, J; Heikkila, P; Leidenius, M; Joensuu, H; Mustjoki, S; Kovanen, P; Eilers, M; Leverson, JD; Klefstrom, J: Pharmacological reactivation of MYC-dependent apoptosis induces susceptibility to anti-PD-1 immunotherapy. In: Nature Communications, 10 , 2019, ISSN: 2041-1723. (Type: Journal Article | Links | BibTeX)
12.Konstantinopoulos, PA; Waggoner, S; Vidal, GA; Mita, M; Moroney, JW; Holloway, R; Van Le, L; Sachdev, JC; Chapman-Davis, E; Colon-Otero, G; Penson, RT; Matulonis, UA; Kim, YB; Moore, KN; Swisher, EM; Farkkila, A; D'Andrea, A; Stringer-Reasor, E; Wang, J; Buerstatte, N; Arora, S; Graham, JR; Bobilev, D; Dezube, BJ; Munster, P: Single-Arm Phases 1 and 2 Trial of Niraparib in Combination With Pembrolizumab in Patients With Recurrent Platinum-Resistant Ovarian Carcinoma. In: JAMA Oncology, 5 (8), pp. 1141-1149, 2019, ISSN: 2374-2437. (Type: Journal Article | Abstract | Links | BibTeX)
13.Pentinmikko, N; Iqbal, S; Mana, M; Andersson, S; Cognetta, AB; Suciu, RM; Roper, J; Luopajarvi, K; Markelin, E; Gopalakrishnan, S; Smolander, OP; Naranjo, S; Saarinen, T; Juuti, A; Pietilainen, K; Auvinen, P; Ristimaki, A; Gupta, N; Tammela, T; Jacks, T; Sabatini, DM; Cravatt, BF; Yilmaz, OH; Katajisto, P: Notum produced by Paneth cells attenuates regeneration of aged intestinal epithelium. In: Nature, 571 (7765), pp. 398–+, 2019, ISSN: 0028-0836. (Type: Journal Article | Links | BibTeX)
14.Fusciello, M; Fontana, F; Tahtinen, S; Capasso, C; Feola, S; Martins, B; Chiaro, J; Peltonen, K; Ylosmaki, L; Ylosmaki, E; Hamdan, F; Kari, OK; Ndika, J; Alenius, H; Urtti, A; Hirvonen, JT; Santos, HA; Cerullo, V: Artificially cloaked viral nanovaccine for cancer immunotherapy. In: Nature Communications, 10 , 2019, ISSN: 2041-1723. (Type: Journal Article | Abstract | Links | BibTeX)
15.Song, E; Mao, TY; Dong, HP; Boisserand, LSB; Antila, S; Bosenberg, M; Alitalo, K; Thomas, JL; Iwasaki, A: VEGF-C-driven lymphatic drainage enables immunosurveillance of brain tumours. In: Nature, 577 (7792), pp. 629–630, 2020, ISSN: 0028-0836. (Type: Journal Article | Links | BibTeX)
16.Dufva O, Koski J, Maliniemi P, Ianevski A, Klievink J, Leitner J, Polonen P, Hohtari H, Saeed K, Hannunen T, Ellonen P, Steinberger P, Kankainen M, Aittokallio T, Keranen MAI, Korhonen M, Mustjoki S. : Integrated drug profiling and CRISPR screening identify essential pathways for CAR T-cell cytotoxicity. In: Blood, 135 (9), pp. 597–609, 2020, ISSN: 0006-4971. (Type: Journal Article | Links | BibTeX)
17.Kuusanmaki, H; Leppa, AM; Polonen, P; Kontro, M; Dufva, O; Deb, D; Yadav, B; Bruck, O; Kumar, A; Everaus, H; Gjertsen, BT; Heinaniemi, M; Porkka, K; Mustjoki, S; Heckman, CA: Phenotype-based drug screening reveals association between venetoclax response and differentiation stage in acute myeloid leukemia. In: Haematologica, 105 (3), pp. 708–720, 2020, ISSN: 0390-6078. (Type: Journal Article | Abstract | Links | BibTeX)
18.Farkkila, A; Gulhan, DC; Casado, J; Jacobson, CA; Nguyen, H; Kochupurakkal, B; Maliga, Z; Yapp, C; Chen, YA; Schapiro, D; Zhou, YH; Graham, JR; Dezube, BJ; Munster, P; Santagata, S; Garcia, E; Rodig, S; Lako, A; Chowdhury, D; Shapiro, GI; Matulonis, UA; Park, PJ; Hautaniemi, S; Sorger, PK; Swisher, EM; D'Andrea, AD; Konstantinopoulos , PA: Immunogenomic profiling determines responses to combined PARP and PD-1 inhibition in ovarian cancer. In: Nature Communications, 11 (1), 2020. (Type: Journal Article | Links | BibTeX)
19.Gao, YJ; Yan, Y; Tripathi, S; Pentinmikko, N; Amaral, A; Paivinen, P; Domenech-Moreno, E; Andersson, S; Wong, IPL; Clevers, H; Katajisto, P; Makela, TP: LKB1 Represses ATOH1 via PDK4 and Energy Metabolism and Regulates Intestinal Stem Cell Fate. In: Gastroenterology, 158 (5), pp. 1389–+, 2020, ISSN: 0016-5085. (Type: Journal Article | Abstract | Links | BibTeX)
20.Nava, MM; Miroshnikova, YA; Biggs, LC; Whitefield, DB; Metge, F; Boucas, J; Vihinen, H; Jokitalo, E; Li, XP; Arcos, JMG; Hoffmann, B; Merkel, R; Niessen, CM; Dahl, KN; Wickstrom, SA: Heterochromatin-Driven Nuclear Softening Protects the Genome against Mechanical Stress-Induced Damage. In: Cell, 181 (4), pp. 800–+, 2020, ISSN: 0092-8674. (Type: Journal Article | Links | BibTeX)
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