TRIMM x iCAN seminar with Prof. Andrew Sewell

Professor Andrew K. Sewell is a distinguished immunologist at Cardiff University’s School of Medicine, where he serves as a Professor in the Division of Infection and Immunity.

We are happy to organise a seminar together with Translational Immunology Program TRIMM with prof. Sewell as the speaker

on Thu 30.1.2025 at 10:30-11:30 UTC+2 in Biomedicum 1, Seminar room 3, and online.
Zoom-link (Meeting ID: 648 0498 6682 Passcode: 366409)

Title: How T-cells cause autoimmune disease and can be used to cure cancer

Host: Prof. Vincenzo Cerullo

Minibio of the speaker:

Prof. Sewell’s research centers on T-cell antigens and their receptors, with a focus on areas such as infection, transplant tolerance, vaccination, cancer immunotherapy, and autoimmune diseases. More recently, his group has shifted its attention to understanding what T-cells target during successful immunotherapy for solid cancers or during natural spontaneous remission. This endeavor has required the development of pipelines to identify the targets of T-cell receptors (TCRs) with unknown specificity. The ultimate goal is to leverage these TCRs and their ligands to create the next generation of cancer therapies.

His most recent work includes:
“MHC-related protein 1-restricted recognition of cancer via a semi-invariant TCR-α chain.” [Dolton et al. 2025 J Clin Invest.] link
“HLA A*24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes” [Dolton et al. 2024 J Clin Invest.] link
“Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy.” [Dolton G et al. 2023 Cell] link

Warm welcome to the seminar and to the public examination of Jacopo Chiaro with Prof. Sewell as the opponent on the following day!