Publications
Read below the 20 most recent publications from iCAN.
- by Alberto LópezMulti-modal learning, in which diverse data types are integrated and analyzed together, has become a central area of research in artificial intelligence, driving major advances in a wide range of domains. However, in many practical situations, certain modalities or variables may be missing for part of the samples, leading to a limited performance or failure […]
- by Emma W ViitalaCancer-associated fibroblasts (CAFs) promote tumorigenesis and represent potential therapeutic targets, highlighting the need for precise understanding of CAF heterogeneity. In colorectal cancer (CRC), CAF subsets and nomenclature vary widely, and many studies overlook the diversity of normal colon fibroblasts that shapes tumor mesenchyme. Here, we combine large-scale single-cell RNA-sequencing analysis with spatial validation and functional […]
- by Sara C DegerholmCONCLUSIONS: Immunohistochemical markers routinely applied in cutaneous melanoma (SOX-10 and PRAME) are also expressed in head and neck mucosal melanoma. Tumour-infiltrating immune cells showed trend toward better survival, as has been previously found out in cutaneous melanoma. Strong p16 positivity may be an independent predictor of favorable prognosis in head and neck mucosal melanoma, irrespective […]
- by Krista JuurikkaMMPs are essential for the physiological tissue turnover within the oral cavity and maxillofacial structures but their dysregulation may lead to pathogenic, tissue-destructive oral diseases. Within oral tissues, matrix metalloproteinases (MMPs) are produced by a variety of cells, including fibroblasts, keratinocytes, epithelial cells, immune cells, osteoclasts, osteoblasts, and odontoblasts. Activation of MMPs in periodontal tissues […]
- by Piia PeltoniemiNo abstract
- by Micaela A MacchioneMagnetic nanodiscs (MNDs) act as nanoscale heaters under high magnetic fields. Here, MNDs were coated with the positively charged thermoresponsive polymer poly(N-isopropylacrylamide-co-2-(dimethylamino)ethyl methacrylate) (P(NIPAM-co-DMAEMA) and evaluated for adenovirus complexation and magnetothermal release, enabling viral delivery by remote regulation of transfection through thermal modulation of electrostatic interactions.
- by Diego GilioliChemotherapy resistance and disease relapse are major determinants of treatment failure in acute myeloid leukemia (AML). Therapy-induced senescence (TIS) is one outcome of chemotherapy, but its immunological consequences in AML remain unclear. Here we show that ex vivo chemotherapy induces senescence in a subset of therapy-naïve AML samples. TIS is marked by elevated interferon signaling, […]
- by Ana PopovićCancer cells utilize filopodia to explore, adhere to and invade their surrounding microenvironment, yet the protein networks that organize these protrusions remain incompletely defined. To uncover the molecular machinery underlying MYO10-positive filopodia, we targeted the fast biotin ligase TurboID to the motor protein MYO10. Proximity biotinylation in two cell types revealed hundreds of potential MYO10 […]
- by Michaela FeodoroffINTRODUCTION: Clear cell renal cell carcinoma (ccRCC) remains a significant therapeutic challenge due to its biological heterogeneity, variable clinical behavior, and limited efficacy of single-agent systemic therapies. Combination strategies targeting multiple tumor-promoting pathways may improve therapeutic outcomes.
- by Linh LinLung cancer, a leading cause of cancer-related mortality, is often driven by mutations in the key oncogenes epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma virus (KRAS). Despite advancements of targeted therapies such as tyrosine kinase inhibitors, resistance remains a significant hurdle. Overexpression of HER3, associated with poor prognosis in non-small cell lung cancer […]
- by Dimitrios TsallosTP53 abnormalities contribute to treatment resistance and poor prognosis in multiple myeloma (MM), yet their functional consequences remain unclear. Here, we integrate ex vivo drug sensitivity profiling, genomics, transcriptomics, and proteomics across 167 CD138^(+) bone marrow patient samples to characterize TP53-associated vulnerabilities. Genome-wide CRISPR-Cas9 and RNAi screening identify vulnerabilities in TP53-mutated MM, with or without […]
- by Niko PaavilainenCONCLUSIONS: Findings derived from case reports and two cohort studies suggest clinically meaningful responses and survival benefits of ICIs in a subset of patients with advanced OMM.
- by Antti S RannikkoConfirmatory prostate-specific antigen measurement reclassifies many younger men below the biopsy threshold, offering a simple, low-cost way to reduce magnetic resonance imaging and biopsy. For most, reclassification means deferral rather than exclusion, and follow-up remains insufficient to rule out missed clinically significant cancers."
- by Sakari KosolaCONCLUSIONS: Nuclear PML expression is associated with favourable outcomes in localised ccRCC and may provide additional prognostic information. Independent validation and mechanistic studies are warranted.
- by Alwine B KruisselbrinkCONCLUSION: Our findings demonstrate that synthetic lethal interactions observed in vector-based models are often a consequence of IDH^(MUT) protein overexpression and supra-physiological D-2-HG levels. These results highlight that relying on artificially created IDH^(MUT) models may lead to the identification of therapeutic vulnerabilities that are not present in IDH^(MUT) tumours, potentially explaining the poor translation of […]
- by Matilda SalkoCONCLUSIONS: A thromboinflammatory phenotype in blood is common in ovarian cancer. Primary surgery and extent of surgery are associated with post-operative venous thromboembolism, whereas perioperative red blood cell transfusions have a protective association. Albumin serves as a prognostic biomarker.
- by Piia M PeltoniemiCONCLUSIONS: In open pancreatoduodenectomy, TEA increases early norepinephrine and fluid requirements without affecting subsequent fluid therapy, complications, or recovery. Despite vasodilation with TEA and higher opioid use with CWI, both techniques yield comparable outcomes and are viable alternatives for pain treatment after open pancreatoduodenectomy.
- by Daria ChernyshevaCONCLUSION AND CLINICAL IMPLICATIONS: The ProBIOPSY consensus defines a contemporary, standardised framework for prostate biopsy. While targeted-based strategies are sufficient for most clinical scenarios, no single biopsy approach provides complete information for all treatment decisions, underscoring the need for indication-specific biopsy tailoring.
- by Negar SafinianainiTo achieve a more comprehensive understanding of cancer, novel computational methods are required for the integrative analysis of data from different molecular layers, such as genomics, transcriptomics, and epigenomics. Here, we present an innovative multi-omics integrative method that performs unsupervised representation learning, referred to as OMIDIENT: multiOMics Integration for cancer by DIrichlet auto-ENcoder neTworks. OMIDIENT […]
- Complex I drives glutamine-dependent TCA cycle to support viability of MYC(high) breast cancer cellsby Johanna M AnttilaIn many cancers, stably elevated MYC levels drive sustained activation of anabolic programs and the cell cycle, creating opportunities for the synthetic-lethal targeting of MYC^(high) tumors. Enhanced mitochondrial respiration is a hallmark of MYC overexpressing cancer cells. Mitochondrial respiration sustains the TCA cycle by regenerating NAD^(+) through complex I-mediated oxidation of NADH, supporting the anabolic […]