Publications
Read below the 20 most recent publications from iCAN.
- by Linh LinLung cancer, a leading cause of cancer-related mortality, is often driven by mutations in the key oncogenes epidermal growth factor receptor (EGFR) and Kirsten rat sarcoma virus (KRAS). Despite advancements of targeted therapies such as tyrosine kinase inhibitors, resistance remains a significant hurdle. Overexpression of HER3, associated with poor prognosis in non-small cell lung cancer […]
- by Dimitrios TsallosTP53 abnormalities contribute to treatment resistance and poor prognosis in multiple myeloma (MM), yet their functional consequences remain unclear. Here, we integrate ex vivo drug sensitivity profiling, genomics, transcriptomics, and proteomics across 167 CD138^(+) bone marrow patient samples to characterize TP53-associated vulnerabilities. Genome-wide CRISPR-Cas9 and RNAi screening identify vulnerabilities in TP53-mutated MM, with or without […]
- by Niko PaavilainenCONCLUSIONS: Findings derived from case reports and two cohort studies suggest clinically meaningful responses and survival benefits of ICIs in a subset of patients with advanced OMM.
- by Antti S RannikkoConfirmatory prostate-specific antigen measurement reclassifies many younger men below the biopsy threshold, offering a simple, low-cost way to reduce magnetic resonance imaging and biopsy. For most, reclassification means deferral rather than exclusion, and follow-up remains insufficient to rule out missed clinically significant cancers."
- by Sakari KosolaCONCLUSIONS: Nuclear PML expression is associated with favourable outcomes in localised ccRCC and may provide additional prognostic information. Independent validation and mechanistic studies are warranted.
- by Alwine B KruisselbrinkCONCLUSION: Our findings demonstrate that synthetic lethal interactions observed in vector-based models are often a consequence of IDH^(MUT) protein overexpression and supra-physiological D-2-HG levels. These results highlight that relying on artificially created IDH^(MUT) models may lead to the identification of therapeutic vulnerabilities that are not present in IDH^(MUT) tumours, potentially explaining the poor translation of […]
- by Matilda SalkoCONCLUSIONS: A thromboinflammatory phenotype in blood is common in ovarian cancer. Primary surgery and extent of surgery are associated with post-operative venous thromboembolism, whereas perioperative red blood cell transfusions have a protective association. Albumin serves as a prognostic biomarker.
- by Piia M PeltoniemiCONCLUSIONS: In open pancreatoduodenectomy, TEA increases early norepinephrine and fluid requirements without affecting subsequent fluid therapy, complications, or recovery. Despite vasodilation with TEA and higher opioid use with CWI, both techniques yield comparable outcomes and are viable alternatives for pain treatment after open pancreatoduodenectomy.
- by Daria ChernyshevaCONCLUSION AND CLINICAL IMPLICATIONS: The ProBIOPSY consensus defines a contemporary, standardised framework for prostate biopsy. While targeted-based strategies are sufficient for most clinical scenarios, no single biopsy approach provides complete information for all treatment decisions, underscoring the need for indication-specific biopsy tailoring.
- by Negar SafinianainiTo achieve a more comprehensive understanding of cancer, novel computational methods are required for the integrative analysis of data from different molecular layers, such as genomics, transcriptomics, and epigenomics. Here, we present an innovative multi-omics integrative method that performs unsupervised representation learning, referred to as OMIDIENT: multiOMics Integration for cancer by DIrichlet auto-ENcoder neTworks. OMIDIENT […]
- Complex I drives glutamine-dependent TCA cycle to support viability of MYC(high) breast cancer cellsby Johanna M AnttilaIn many cancers, stably elevated MYC levels drive sustained activation of anabolic programs and the cell cycle, creating opportunities for the synthetic-lethal targeting of MYC^(high) tumors. Enhanced mitochondrial respiration is a hallmark of MYC overexpressing cancer cells. Mitochondrial respiration sustains the TCA cycle by regenerating NAD^(+) through complex I-mediated oxidation of NADH, supporting the anabolic […]
- by Emil A PetterssonCONCLUSIONS: The prevalence of periodontitis among patients undergoing gastric surgery matched that of the general population in Finland. Periodontitis did not associate with postoperative complications in surgical patients.
- by Gabriella AntignaniImmunotherapy has revolutionized cancer treatment, yet clinical success remains limited, with only a fraction of patients responding. Tumor heterogeneity and patient-specificity hinder response prediction, emphasizing the need for human-based models that accurately reproduce tumor-immune interactions. Conventional preclinical platforms, such as murine models, lack the human-specific HLA-TCR complexity, limiting their ability to accurately evaluate immunotherapy responses. […]
- by Jarmo RitariLichen planus (LP) is an inflammatory disease affecting squamous epithelia, typically manifesting in a cutaneous (non-OLP) and an oral mucosa (OLP) form, the latter conferring elevated risk of oral squamous cell carcinoma. Despite the presence of CD4+ and CD8+ T-cell infiltrates in LP lesions, specific autoantibodies or target T-cell antigens have not been identified. A […]
- by Ricardo D ColettaAlthough a wide range of molecular and histopathological biomarkers has been explored for oral squamous cell carcinoma (OSCC), few have reached the level of validation needed for routine clinical application. Updates to the TNM staging system and accumulating evidence for emerging histopathological parameters may enhance prognostic accuracy, but robust prospective studies are still required. Progress […]
- by Aino-Elina HäkkinenCytomegalovirus (CMV) reactivation reshapes immune reconstitution and remains a significant cause of morbidity and mortality after allogeneic hematopoietic stem cell transplantation (HSCT). To understand the impact of asymptomatic CMV viremia on immune reconstitution, we profiled longitudinal blood samples (n = 32) from donor-recipient pairs before and after HSCT with single-cell RNA and T-cell receptor (TCR) […]
- by Nemo IkonenChromosome 7 abnormalities -7 and -7q define a high-risk subset of myelodysplastic syndromes (MDS) with poor prognosis. The NAMPT gene, located at 7q22.3, encodes a rate limiting enzyme (nicotinamide phosphoribosyl transferase) in the NAD+ salvage pathway. Several inhibitors of NAMPT have been developed, but their activity in MDS has not been previously described. In this […]
- by Laura LangohrERCC6L2 disease (ED) is a rare bone marrow failure syndrome caused by biallelic germline mutations in ERCC6L2. ED leads to the accumulation of somatic TP53 mutations, myelodysplastic syndrome, and acute myeloid leukemia (AML) with erythroid predominance and poor prognosis. While ERCC6L2 is implicated in DNA replication and repair, the transcriptomic events underlying delayed erythropoiesis and […]
- by Zeynep IlogluPolybrene, also known as a common name hexadimethrine bromide, is a reagent widely used to improve the transduction efficiency of viral vectors. Although polybrene has been used for studying glioblastoma cells, its cytotoxicity on these cells has not been systematically addressed. Glioblastoma is one of the most aggressive types of brain tumors, associated with poor […]
- by L LeinonenCONCLUSIONS: Current evidence does not support Bcl-xL as a general prognostic marker in head and neck squamous cell carcinoma. Nevertheless, Bcl-xL may have prognostic relevance in oral tongue cancer if further studies confirm the original finding.