Photo of Andrew Sewell and event information

TRIMM x iCAN seminar with Prof. Andrew Sewell

Professor Andrew K. Sewell is a distinguished immunologist at Cardiff University’s School of Medicine, where he serves as a Professor in the Division of Infection and Immunity.

We are happy to organise a seminar together with Translational Immunology Program TRIMM with prof. Sewell as the speaker

on Thu 30.1.2025 at 10:30-11:30 UTC+2 in Biomedicum 1, Seminar room 3, and online.
Zoom-link (Meeting ID: 648 0498 6682 Passcode: 366409)

Title: How T-cells cause autoimmune disease and can be used to cure cancer

Host: Prof. Vincenzo Cerullo

Minibio of the speaker:

Prof. Sewell’s research centers on T-cell antigens and their receptors, with a focus on areas such as infection, transplant tolerance, vaccination, cancer immunotherapy, and autoimmune diseases. More recently, his group has shifted its attention to understanding what T-cells target during successful immunotherapy for solid cancers or during natural spontaneous remission. This endeavor has required the development of pipelines to identify the targets of T-cell receptors (TCRs) with unknown specificity. The ultimate goal is to leverage these TCRs and their ligands to create the next generation of cancer therapies.

His most recent work includes:
“MHC-related protein 1-restricted recognition of cancer via a semi-invariant TCR-α chain.” [Dolton et al. 2025 J Clin Invest.] link
“HLA A*24:02-restricted T cell receptors cross-recognize bacterial and preproinsulin peptides in type 1 diabetes” [Dolton et al. 2024 J Clin Invest.] link
“Targeting of multiple tumor-associated antigens by individual T cell receptors during successful cancer immunotherapy.” [Dolton G et al. 2023 Cell] link

Warm welcome to the seminar and to the public examination of Jacopo Chiaro with Prof. Sewell as the opponent on the following day!

iCAN is part of the Research Council of Finland Flagship Programme with the University of Helsinki and HUS Helsinki University Hospital as founding partners.

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ican@helsinki.fi

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