Programme

8:00-9:00 Coffee
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Session 4: From bench to bedside
Chairs: Päivi Ojala and Anniina Färkkilä

9:00-10:00 Invited talks
Metabolic rewiring driving metastasis formation
Sarah-Maria Fendt, VIB Center for Cancer Biology

Harnessing cancer and immune cell communication to identify new therapeutic targets
Elisa Oricchio, ISREC – Swiss Institute for Experimental Cancer Research, EPFL

Transcriptional determinants of carcinogenesis
Sakari Vanharanta, University of Helsinki

10:00-10:20 Two selected talks

Tumor immune microenvironment dictates immunotherapy responses in lung cancer
Heidi Haikala, University of Helsinki & Tampere University

Integrated Multi-omics Profiling of Cell Cycle Checkpoint Blockade Responses in Ovarian Cancer
Juuli Raivola, University of Helsinki
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10:20-11:00 Coffee break and exhibition
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Session 5: Precision cancer medicine
Chairs: Caroline Heckman and Sirpa Leppä

11:00-12:00 Invited talks

A new lens on precision medicine… guiding therapy through single-cell direct response testing
Philipp Staber, Saarland University

Integrating Genomics and Biomarkers for Patient Selection in Phase I Precision Oncology Trials

Kristoffer Rohrberg, University Hospital of Copenhagen

Does precision cancer medicine benefit patients when standard therapy has failed? Experiences from the FINPROVE study
Katriina Jalkanen, Helsinki University Central Hospital

12:00-12:10 Selected talk

A Comprehensive Clinical Decision Support Tool: integrative Molecular Tumor Board (iMTB)
Tamara Luck, University of Helsinki
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12:10-12:20 Poster prizes and conclusion of the symposium
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12:20 Lunch and farewell

1 Folate Receptor Beta Targeting of Tumor-associated Macrophages  Improves Lymphoma Cell Responses to CD19 CAR T Cells, Kerttu Kalander

2 Epigenetic biomarkers for classification, diagnosis, and treatment of pediatric solid tumors, Caroline Högel-Starck

3 Uncovering synergistic and pre-sensitizing agents to FLT3 inhibitors in acute myeloid leukemia with lineage tracing, Johanna Eriksson

4 FABP3 promotes brain metastasis formation, Sara Ranta

5 Spatial Transcriptomics Reveals Spatially Distinct Fibroblast Gene Signatures in High-Grade Serous Carcinoma, Nika Mikhailava

6 Short fragment fraction of mononucleosomal cfDNA dynamically detects high-risk patients with large B-cell lymphoma, Amos Bonsdorff

7 Prediction of platinum-based neoadjuvant chemotherapy response in muscle-invasive bladder cancer using a multifaceted approach, Arian Askari           

8 Deciphering Heterogeneity in Acute Myeloid Leukemia to Understand the Mechanisms of Disease Progression and Immune Interactions using Single-Cell RNA-Sequencing, Sadiksha Adhikari

9 Oxygen sensing and protein modification pathways in renal cell carcinoma (RCC) – new drug targets and progression markers, Iida Payne

10 Cancer drugs target Cajal bodies to reprogram RNA regulation in prostate cancer cells, Minttu Kärkkäinen

11 Spatial associations of markers of oxidative stress in distinct cell populations in primary triple-negative breast cancer, Wenqing Chen

12 Targeting Interacting Pathways Between Cancer Cells and Fibroblasts in Prostate Cancer, Frida Rantanen

13 SRSF3 shapes the structure and processing of miR-17-92 cluster in colorectal cancer, Jenni Rapakko

14 Hypoxia shapes Tumor Immune Microenvironment Through Cell-Type Dependent Responses in Diffuse Astrocytomas, Iida Salonen

15 Efficacy of the JAK2/FLT3 inhibitor pacritinib in NPM1 mutated acute myeloid leukemia, Eva Daniela Ortiz Mendoza

16 EP300/CREBBP acetyltransferase inhibition limits steroid receptor and FOXA1 signaling in prostate cancer cells, Jasmin Huttunen

17 When One Is Not Enough: A Systems Medicine Approach for Combinatorial Therapy in Acute Myeloid Leukemia, Mohieddin Jafari

18 Fecal profiling reveals a common microbial signature for pancreatic cancer in Finnish and Iranian cohorts, Heidelinde Sammallahti

19 p63-GATA2 molecular switch mediates the tumor suppressor to oncogene transition of glucocorticoid receptor in the prostate, Johannes Hiltunen

20 Unraveling the Role of SOX18 Pioneer Function in KSHV Biology and Kaposi Sarcoma Tumorigenesis – Implications for Therapeutic Utility, Peyton Staab

21 Integrated analysis of longitudinal cell-free DNA and matched tumor profiling data to identify novel breast cancer biomarkers, Daniyar Karabayev

22 Multiparameter imaging reveals clinically relevant cancer cell-stroma interaction dynamics in head and neck cancer, Karolina Punovuori

23 EPSTI1 is an epithelial modulator of chemotherapy response in colorectal cancer, Erdogan Pekcan Erkan

24 The Hunt for Prognostic and Diagnostic Blood-Based Biomarkers in Lung Cancer Immunotherapy, Milos Gojkovic

25 Whole exome sequencing and RNA-based pan-cancer profiling of 2,723 iCAN samples, Nora Schreiber

26 Translational Potential of Stromal Lysosome  Destabilization in Pancreatic Cancer, Sowndharya Sankar Perumal

27 Tumor infiltrating basophils are associated with improved prognosis in colorectal cancer, Oskari Rahkola

28 Metabolic heterogeneity in intestinal adenoma initiation, Johanna Aspholm

29 PARP inhibition enhances the antitumor activity of HER3-DXd in non-small cell lung cancer, Linh Lin

30 Functional Role of Tumor-Derived Extracellular Matrix in Breast Cancer Initiation, Priyal Dhawan

31 Precision network medicine for cancer patient stratification, Panos Sarantidis

32 Hooked to Targets: Antibody-Drug Conjugates in the Treatment of High-Grade Serous Carcinoma, Elsi Pöllänen

33 Cell type specific characterization of prostate cancer gene signatures with spatial transcriptomics in targeted biopsies, Hanna Nebelung

34 Multi-omics and Functional Drug Testing in Pediatric Sarcomas: Clinical Translation via The integrative Molecular Tumor Board (iMTB) tool, Enni Martikainen

35 Unlocking immune potential in EGFR-mutated lung cancer using proteasomal degradation, Narges Moradi

36 Transcriptome and TCR repertoire in human telomerase reverse transcriptase peptide vaccine treated metastatic prostate cancer patients, Alfonso Urbanucci

37 BMI1: A Novel Prognostic Biomarker in High-Grade Serous Carcinoma, Lilla Csellar

38 Matrix stiffness modulates androgen response genes and chromatin state in prostate cancer, Kirsi Ketola

39 The Impact of the Tumor Microenvironment on Drug Sensitivity in Ovarian Cancer, Elina Multamäki

40 Functional Precision Medicine for Clear Cell Renal Cell Carcinoma – From Multi-omics and Drug Testing of Patient-derived Ex Vivo Models to Clinical Translation, Michaela Feodoroff

41 MorphoNavigator-3D: Delivering translational impact through high-throughput 3D single-cell phenotyping of patient-derived cancer models, Isabel Cristina Mogollon

42 Immune landscape characterization of relapsed/refractory B-cell lymphoma patients treated with CD19 CAR T cell therapy, Selma Sorri

43 PRC2 subunits as molecular targets in metastatic prostate cancer, Eerika Takala

44 Therapeutic targeting of the transcriptional kinase CDK9 and CDK11 in breast cancer, Yuqing Bai

45 Genetic alterations in acute myeloid leukemia define susceptibility to NK cell-mediated killing, Hanna Duàn

46 Developing a tool to map transcriptional stress-induced remodeling of the RNA polymerase II complex, Jing Liang

47 Machine Learning Network-Based Stratification Refines Prognosis and Treatment Stratification in Intermediate-Risk AML, Ankita Srivastava

48 Spatial mapping of tumor ecosystems reveals niches associated with immune escape in chemo-naive ovarian cancer, Ziqi Kang

49 Identifying androgen deprivation-induced responses in prostate cancer with single cell multiomic analysis, Iina Koivisto

50 SIX2 promotes cell plasticity via Wnt/β-catenin signalling in androgen receptor independent prostate cancer, Noora Leppänen

51 Mass Cytometry Approach for Quantitative Analysis of Stemness in Cancer, Elisa Närvä

52 Inference and Evaluation of 10,000 Patients’ Cancer Treatment Outcomes from Electronic Health Records Using Large Language Models, Alexey Ryzhenkov

53 Single-Cell Stress Recording: Exploring Stress induced Chemoresistance in ovarian cancer with scRNAseq, Joona Jäntti

54 Single-Cell Multi-Omics Identifies Growth Signaling and Survival Mechanisms Underlying Resistance in BRAF-Mutant Melanoma, Iris Purma

55 Prognostic Value and Characteristics of Cancer Stem Cells In Ovarian Cancer Treatment Resistance, Anna Hämäläinen

56 Characterizing the early proteomic anti-androgen response in prostate cancer cells to understand mechanisms enabling survival and development of resistance, Erika Aikio

57 Molecular profiling of longitudinal samples from acute myeloid leukemia patients before and after VEN+AZA treatment unveils relapse mechanisms, Joseph Saad

58 Regulatory T cells predict improved survival in colorectal cancer: A multiplex immunohistochemistry study, Aino Ojanperä

59 Decoding innate immunity to improve lung cancer outcomes, Hanna Laitinen

60 High-resolution integrative analysis allows characterization and spatial annotation of normal and cancer-associated colon fibroblasts, Emma Viitala


Venue

Little Finlandia
Located in the heart of Helsinki, the Little Finlandia (Karamzininranta 4, 00100 Helsinki) offers easy access and beautiful views of a scenic park and Töölönlahti Bay.

There are easy and frequent public transport connections from the airport, bus and train stations. Tram and bus stops are in the immediate vicinity of the house. Next to the Finlandia building there is a parking garage, Aimo Park, with the following lift connections: Karamzininranta 2 and the elevator hall of the Finlandia Hall building (closest to Little Finlandia). The drive to the parking garage takes place via Karamzininranta. Parking is available for a fee.

Dinner will be served at Hesperia Ballroom at the Crowne Plaza Helsinki (Mannerheimintie 50, 00260 Helsinki).

Registration

Registration: Registration and the waiting list are now closed. The symposium is currently at full capacity. For those on the waiting list, please note that we are exploring the possibility of increasing the number of participants. We’ll be reaching out next week to waitlisted participants, in the order registrations were received, if spots become available.

Symposium fees
Please note that a registration fee of 35€ is required from all the participants to attend the event. The registration fee covers two lunches, coffee breaks, and cloak room services during the symposium. A dinner fee of 30€ applies if you wish to join the dinner on 25.9.

For the sponsors, the registration and dinner fees are included in the sponsorship agreement.

Credits
The symposium is suitable as a theoretical course-based training in the fields of pathology, clinical hematology, and oncology, with a duration of 8 hours at the University of Helsinki. The training can also be included in the theoretical studies of a Doctor of Medicine or Doctor of Philosophy degree, corresponding to 0.7 ECTS credits.

Sponsors



The exhibition area will be located in the Little Finlandia foyer.


Scientific Organizing Committee
Anniina Färkkilä (Chair), Assoc. Prof., University of Helsinki and Helsinki University Hospital
Sirpa Leppä (Chair), Professor, University of Helsinki and Helsinki University Hospital
Caroline Heckman, Research Director, University of Helsinki
Tuomas Mirtti, Professor, University of Helsinki and Helsinki University Hospital
Päivi Ojala, Professor, University of Helsinki
Esa Pitkänen, FIMM-EMBL Group Leader, University of Helsinki
Thomas Hackman, iCAN Patient and Citizen Advisory Board

Tiina Vesterinen, Managing Director, Finnish Cancer Institute

iCAN core
Helene Wahl, Satu Sankkila, Marketta Liljeström

iCANDOC
Mila Hyytinen, Piia-Riitta Karhemo

iCAN is part of the Research Council of Finland Flagship Programme with the University of Helsinki and HUS Helsinki University Hospital as founding partners.

Please get in touch:

ican@helsinki.fi

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